PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Leukotriene B4-d5
0 ImagesCat. No.: HY-107608S1Synonyms: LTB4-d5Leukotriene B4-d5 (LTB4-d5) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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m-PEG16-Br
0 ImagesCat. No.: HY-133281CAS No.: 1238189-11-1
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Thalidomide-O-PEG1-OH
0 ImagesCat. No.: HY-W990229CAS No.: 2416234-31-4Thalidomide-O-PEG1-OH is a PROTAC linker featuring thalidomide with an O-ethyl alcohol. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction. Meanwhile, the hydroxyl is a versatile handle for forming more complex structures through a number of reactions.
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tert-Butyl N-(3-[(3-aminopropyl)(methyl)amino]propyl)carbamate
![tert-Butyl N-(3-[(3-aminopropyl)(methyl)amino]propyl)carbamate](https://file.medchemexpress.com/product_pic/hy-w154276.gif "Click to View tert-Butyl N-(3-[(3-aminopropyl)(methyl)amino]propyl)carbamate Product Detail")
0 ImagesCat. No.: HY-W154276CAS No.: 87530-14-1
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Henicosanedioic acid
0 ImagesCat. No.: HY-W583733CAS No.: 505-55-5
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2-(4-(2-Hydroxyethyl)piperazin-1-yl)acetic acid
0 ImagesCat. No.: HY-W267532CAS No.: 124335-65-5
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tert-Butyl (trans-3-(aminomethyl)cyclobutyl)carbamate
0 ImagesCat. No.: HY-WAA0307CAS No.: 1214727-57-7
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11-Aminoundecan-1-ol
0 ImagesCat. No.: HY-W357366CAS No.: 27780-89-8
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Hex-5-yn-1-amine hydrochloride
0 ImagesCat. No.: HY-W023192CAS No.: 102169-54-0
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(S)-TCO-PEG4-acid
0 ImagesCat. No.: HY-141159A
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Benzyl (4-aminobutyl)carbamate
0 ImagesCat. No.: HY-W244921CAS No.: 62146-62-7
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tert-Butyl 2-(piperazin-1-yl)acetate hydrochloride
0 ImagesCat. No.: HY-W613965CAS No.: 2408342-38-9
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BG-PEG8-Amine
0 ImagesCat. No.: HY-W1130397
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Acid-PEG8-S-S-PEG8-acid
0 ImagesCat. No.: HY-W096114CAS No.: 873013-93-5
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PEG1-bis(4,4,5,5-tetramethyl-2-phenyl-1,3,2-dioxaborolane)
0 ImagesCat. No.: HY-W121472CAS No.: 957061-07-3
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Fmoc-L-Lys(Boc-AEEA-AEEA)-OH
0 ImagesCat. No.: HY-402648CAS No.: 1662688-18-7Fmoc-L-Lys(Boc-AEEA-AEEA)-OH is the derivative of AEEA-AEEA (HY-W125504). AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
